Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies

Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is heterogeneous in etiology, phenotype and biology. Patient-derived xenografts (PDX) maintain morphology and molecular profiling of the original tumors and have become a standard “Avatar” model for human cancer research. However, res...

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Bibliographic Details
Main Authors: Daniel Strüder, Theresa Momper, Nina Irmscher, Mareike Krause, Jan Liese, Sebastian Schraven, Annette Zimpfer, Sarah Zonnur, Ann-Sophie Burmeister, Björn Schneider, Bernhard Frerich, Robert Mlynski, Christina Große-Thie, Christian Junghanss, Claudia Maletzki
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Primary cancer
HPV positive and negative
Individual tumor models
Immune cell infiltration
Recurrence
Metastasis
Online Access:https://doi.org/10.1186/s13046-021-02047-w

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