Activation of GABAA Receptors in Colon Epithelium Exacerbates Acute Colitis

Activation of GABAA Receptors in Colon Epithelium Exacerbates Acute Colitis

Emerging evidence indicates that gamma-aminobutyric acid (GABA) has many beneficial effects such as ameliorating immune and inflammatory response. But, here we reported that activation of GABAA receptors (GABAA Rs) aggravated dextran sulfate sodium (DSS)-induced colitis, although the expression of p...

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Bibliographic Details
Main Authors: Xuelian Ma, Qian Sun, Xiaotong Sun, Dawei Chen, Chuanfei Wei, Xin Yu, Chuanyong Liu, Yanqing Li, Jingxin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
gamma-aminobutyric acid
ulcerative colitis
mucosal barrier
epithelial proliferation
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00987/full

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