The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype

The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype

Recent studies have shown that Borrelia burgdorferi can form antibiotic-tolerant persisters in the presence of microbiostatic drugs such as doxycycline. Precisely how this occurs is yet unknown. Our goal was to examine gene transcription by B. burgdorferi following doxycycline treatment in an effort...

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Bibliographic Details
Main Authors: John R. Caskey, Nicole R. Hasenkampf, Dale S. Martin, Vladimir N. Chouljenko, Ramesh Subramanian, Mercedes A. Cheslock, Monica E. Embers
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
Lyme disease
antibiotic
Borrelia (Borreliella) burgdorferi
RNASeq analysis
mice
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00690/full

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