Effect of erythropoietin combined with interventional therapy on cardiac function injury and inflammation in patients with STEMI

• Main Author: You-Gen Zhou
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: ST-elevation myocardial infarction Erythropoietin Interventional therapy Cardiac function Inflammatory response
• Online Access: http://www.hnykdxxb.com/PDF/201707/6.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the effect of erythropoietin combined with interventional therapy on cardiac function injury and inflammation in patients with STEMI. Methods: 58 patients with STEMI treated in our hospital between April 2012 and September 2015 were selected, the treatment methods and test results were reviewed, and then they were divided into the control group who accepted interventional therapy alone and the observation group who accepted erythropoietin combined with interventional therapy. Before and after treatment, color Doppler diasonograph was used to detect cardiac function parameters; immune scatter turbidimetry was used to determine myocardial injury marker levels in peripheral blood; ELISA was used to detect serum inflammatory factor levels. Results: Before treatment, differences in cardiac function parameter levels, myocardial injury marker contents and inflammatory factor contents were not statistically significant between two groups of patients (P>0.05). After treatment, cardiac function parameters LvEDD and LVESD levels of observation group were significantly lower than those of control group while EV and AV levels were significantly higher than those of control group (P<0.05); serum myocardial injury indexes ICTP and IMA contents of observation group were significantly lower than those of control group while CysC content was significantly higher than that of control group (P<0.05); serum inflammatory factors CRP, IL-18, IL-27 and MDC contents of observation group were significantly lower than those of control group while IL-10 content was significantly higher than that of control group (P<0.05). Conclusion: Erythropoietin combined with interventional therapy can play a positive role in myocardial protection, improve cardiac pump function, reduce myocardial cell injury and inhibit inflammatory response.