Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

Cell senescence involves stable arrest of cell proliferation and changes in gene expression and 3D genome reorganization. Here, the authors show that human condensin II complex participates in reorganization of the chromatin compartments, primarily through switching from heterochromatic B to euchrom...

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Main Authors: Osamu Iwasaki, Hideki Tanizawa, Kyoung-Dong Kim, Andrew Kossenkov, Timothy Nacarelli, Sanki Tashiro, Sonali Majumdar, Louise C. Showe, Rugang Zhang, Ken-ichi Noma
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13604-5
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spelling doaj-d6bfd9f78d8e46fe944d870a5010386b2021-05-11T11:54:40ZengNature Publishing GroupNature Communications2041-17232019-12-0110112010.1038/s41467-019-13604-5Involvement of condensin in cellular senescence through gene regulation and compartmental reorganizationOsamu Iwasaki0Hideki Tanizawa1Kyoung-Dong Kim2Andrew Kossenkov3Timothy Nacarelli4Sanki Tashiro5Sonali Majumdar6Louise C. Showe7Rugang Zhang8Ken-ichi Noma9Institute of Molecular Biology, University of OregonInstitute of Molecular Biology, University of OregonDepartment of Systems Biotechnology, Chung-Ang UniversityThe Wistar InstituteThe Wistar InstituteInstitute of Molecular Biology, University of OregonThe Wistar InstituteThe Wistar InstituteThe Wistar InstituteInstitute of Molecular Biology, University of OregonCell senescence involves stable arrest of cell proliferation and changes in gene expression and 3D genome reorganization. Here, the authors show that human condensin II complex participates in reorganization of the chromatin compartments, primarily through switching from heterochromatic B to euchromatic A compartments.https://doi.org/10.1038/s41467-019-13604-5
collection DOAJ
language English
format Article
sources DOAJ
author Osamu Iwasaki
Hideki Tanizawa
Kyoung-Dong Kim
Andrew Kossenkov
Timothy Nacarelli
Sanki Tashiro
Sonali Majumdar
Louise C. Showe
Rugang Zhang
Ken-ichi Noma
spellingShingle Osamu Iwasaki
Hideki Tanizawa
Kyoung-Dong Kim
Andrew Kossenkov
Timothy Nacarelli
Sanki Tashiro
Sonali Majumdar
Louise C. Showe
Rugang Zhang
Ken-ichi Noma
Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
Nature Communications
author_facet Osamu Iwasaki
Hideki Tanizawa
Kyoung-Dong Kim
Andrew Kossenkov
Timothy Nacarelli
Sanki Tashiro
Sonali Majumdar
Louise C. Showe
Rugang Zhang
Ken-ichi Noma
author_sort Osamu Iwasaki
title Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
title_short Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
title_full Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
title_fullStr Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
title_full_unstemmed Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
title_sort involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description Cell senescence involves stable arrest of cell proliferation and changes in gene expression and 3D genome reorganization. Here, the authors show that human condensin II complex participates in reorganization of the chromatin compartments, primarily through switching from heterochromatic B to euchromatic A compartments.
url https://doi.org/10.1038/s41467-019-13604-5
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AT hidekitanizawa involvementofcondensinincellularsenescencethroughgeneregulationandcompartmentalreorganization
AT kyoungdongkim involvementofcondensinincellularsenescencethroughgeneregulationandcompartmentalreorganization
AT andrewkossenkov involvementofcondensinincellularsenescencethroughgeneregulationandcompartmentalreorganization
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AT sankitashiro involvementofcondensinincellularsenescencethroughgeneregulationandcompartmentalreorganization
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AT kenichinoma involvementofcondensinincellularsenescencethroughgeneregulationandcompartmentalreorganization
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