Uncovering the subtype-specific temporal order of cancer pathway dysregulation.

Cancer is driven by genetic mutations that dysregulate pathways important for proper cell function. Therefore, discovering these cancer pathways and their dysregulation order is key to understanding and treating cancer. However, the heterogeneity of mutations between different individuals makes this...

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Bibliographic Details
Main Authors: Sahand Khakabimamaghani, Dujian Ding, Oliver Snow, Martin Ester
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-11-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007451