Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin

Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin

Feedback control is a universal feature of cell signaling pathways. Naked/NKD is a widely conserved feedback regulator of Wnt signaling which controls animal development and tissue homeostasis. Naked/NKD destabilizes Dishevelled, which assembles Wnt signalosomes to inhibit the β-catenin destruction...

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Bibliographic Details
Main Authors: Melissa V Gammons, Miha Renko, Joshua E Flack, Juliusz Mieszczanek, Mariann Bienz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
Naked/NKD
histidine cluster
Dishevelled
p62 autophagy receptor
feedback control
Axin degradation
Online Access:https://elifesciences.org/articles/59879

Internet

https://elifesciences.org/articles/59879

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