Pharmacological Effects of Verticine: Current Status

Pharmacological Effects of Verticine: Current Status

Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expe...

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Main Authors: Zhenhua Yin, Juanjuan Zhang, Qingfeng Guo, Lin Chen, Wei Zhang, Wenyi Kang
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2019/2394605
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spelling doaj-d6b2622c829d42a9b33930443b5c34f72020-11-24T22:02:23ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/23946052394605Pharmacological Effects of Verticine: Current StatusZhenhua Yin0Juanjuan Zhang1Qingfeng Guo2Lin Chen3Wei Zhang4Wenyi Kang5Zhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, ChinaZhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, ChinaZhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, ChinaZhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, ChinaZhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, ChinaZhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, ChinaVerticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine.http://dx.doi.org/10.1155/2019/2394605
collection DOAJ
language English
format Article
sources DOAJ
author Zhenhua Yin
Juanjuan Zhang
Qingfeng Guo
Lin Chen
Wei Zhang
Wenyi Kang
spellingShingle Zhenhua Yin
Juanjuan Zhang
Qingfeng Guo
Lin Chen
Wei Zhang
Wenyi Kang
Pharmacological Effects of Verticine: Current Status
Evidence-Based Complementary and Alternative Medicine
author_facet Zhenhua Yin
Juanjuan Zhang
Qingfeng Guo
Lin Chen
Wei Zhang
Wenyi Kang
author_sort Zhenhua Yin
title Pharmacological Effects of Verticine: Current Status
title_short Pharmacological Effects of Verticine: Current Status
title_full Pharmacological Effects of Verticine: Current Status
title_fullStr Pharmacological Effects of Verticine: Current Status
title_full_unstemmed Pharmacological Effects of Verticine: Current Status
title_sort pharmacological effects of verticine: current status
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2019-01-01
description Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine.
url http://dx.doi.org/10.1155/2019/2394605
work_keys_str_mv AT zhenhuayin pharmacologicaleffectsofverticinecurrentstatus
AT juanjuanzhang pharmacologicaleffectsofverticinecurrentstatus
AT qingfengguo pharmacologicaleffectsofverticinecurrentstatus
AT linchen pharmacologicaleffectsofverticinecurrentstatus
AT weizhang pharmacologicaleffectsofverticinecurrentstatus
AT wenyikang pharmacologicaleffectsofverticinecurrentstatus
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