Granulocyte colony-stimulating factor (G-CSF) treatment in combination with transplantation of bone marrow cells is not superior to G-CSF treatment alone after cortical stroke in spontaneously hypertensive rats

Granulocyte colony-stimulating factor (G-CSF) treatment in combination with transplantation of bone marrow cells is not superior to G-CSF treatment alone after cortical stroke in spontaneously hypertensive rats

Granulocyte-colony stimulating factor (G-CSF) and bone marrow derived mononuclear cells (BM-MNC) have both been shown to improve functional outcome following experimental stroke. These effects are associated with increased angiogenesis and neurogenesis. In the present study, we aimed to determine sy...

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Bibliographic Details
Main Authors: Kai eDiederich, Antje eSchmidt, Carolin eBeuker, Jan-Kolja eStrecker, Daniel-Christoph eWagner, Johannes eBoltze, Wolf eSchäbitz, Jens eMinnerup
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Bone Marrow Cells
Neurogenesis
Stroke
Angiogenesis
Neuroregeneration
functional recovery
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00411/full

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