Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

Trapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.

Bibliographic Details
Main Authors: Catherine G. Vasilopoulou, Karolina Sulek, Andreas-David Brunner, Ningombam Sanjib Meitei, Ulrike Schweiger-Hufnagel, Sven W. Meyer, Aiko Barsch, Matthias Mann, Florian Meier
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14044-x
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spelling doaj-d6a409c3b2024cd59469965a92c595662021-05-11T09:08:23ZengNature Publishing GroupNature Communications2041-17232020-01-0111111110.1038/s41467-019-14044-xTrapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amountsCatherine G. Vasilopoulou0Karolina Sulek1Andreas-David Brunner2Ningombam Sanjib Meitei3Ulrike Schweiger-Hufnagel4Sven W. Meyer5Aiko Barsch6Matthias Mann7Florian Meier8Max Planck Institute of BiochemistryNNF Center for Protein ResearchMax Planck Institute of BiochemistryPREMIER BiosoftBruker Daltonik GmbHBruker Daltonik GmbHBruker Daltonik GmbHMax Planck Institute of BiochemistryMax Planck Institute of BiochemistryTrapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.https://doi.org/10.1038/s41467-019-14044-x
collection DOAJ
language English
format Article
sources DOAJ
author Catherine G. Vasilopoulou
Karolina Sulek
Andreas-David Brunner
Ningombam Sanjib Meitei
Ulrike Schweiger-Hufnagel
Sven W. Meyer
Aiko Barsch
Matthias Mann
Florian Meier
spellingShingle Catherine G. Vasilopoulou
Karolina Sulek
Andreas-David Brunner
Ningombam Sanjib Meitei
Ulrike Schweiger-Hufnagel
Sven W. Meyer
Aiko Barsch
Matthias Mann
Florian Meier
Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
Nature Communications
author_facet Catherine G. Vasilopoulou
Karolina Sulek
Andreas-David Brunner
Ningombam Sanjib Meitei
Ulrike Schweiger-Hufnagel
Sven W. Meyer
Aiko Barsch
Matthias Mann
Florian Meier
author_sort Catherine G. Vasilopoulou
title Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_short Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_full Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_fullStr Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_full_unstemmed Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_sort trapped ion mobility spectrometry and pasef enable in-depth lipidomics from minimal sample amounts
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description Trapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.
url https://doi.org/10.1038/s41467-019-14044-x
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