Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma

Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) correlates with immune cell infiltration in...

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Bibliographic Details
Main Authors: Natacha Bordry, Maria A. S. Broggi, Kaat de Jonge, Karin Schaeuble, Philippe O. Gannon, Periklis G. Foukas, Esther Danenberg, Emanuela Romano, Petra Baumgaertner, Manuel Fankhauser, Noémie Wald, Laurène Cagnon, Samia Abed-Maillard, Hélène Maby-El Hajjami, Timothy Murray, Kalliopi Ioannidou, Igor Letovanec, Pu Yan, Olivier Michielin, Maurice Matter, Melody A. Swartz, Daniel E. Speiser
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:OncoImmunology
Subjects:
immunotherapy
lymphatics
tumor immunology
t cell inhibition
t cell promotion
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1462878

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