Renoprotective effect of Eryngium caucasicum in Gentamicin-induced nephrotoxic mice

• Main Authors: Eslami S.H., Ebrahimzadeh M.A., Moghaddam Hajizadeh A., Nabavi S.F., Jafari N., Nabavi S.M.
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2011-01-01
• Series: Archives of Biological Sciences
• Subjects: Eryngium caucasicum; renotoxicity; Gentamicin; creatinine; urea; BUN
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641101157E.pdf
• ISSN: 0354-4664

Recent studies show that hydrogen peroxide free radicals have an important role in the renal damage induced by Gentamicin. Previously we studied the hydrogen peroxide scavenging activity of Eryngium caucasicum. This work was conducted to evaluate the possible renoprotective effect of Eryngium caucasicum against Gentamicin-induced renotoxicity. Extracts at the doses 200 and 400 mg/kg/day for 10 consecutive days, by intraperitoneal route (i.p.) offered renoprotective action by change in the blood urea nitrogen (BUN), serum urea and creatinine. Results show that an extract at 400 mg/kg/ day shows better activity than other tested samples. In conclusion, the extracts showed significant renoprotective activity compared with the control group.