Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAo-induced ischemic brain injury

Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAo-induced ischemic brain injury

Treatments that could extend the therapeutic window of opportunity for stroke patients are urgently needed. Early administration of hyperbaric oxygen therapy (HBOT) has been proven neuroprotective in the middle cerebral artery occlusion (MCAo) in rodents. Our aim was to determine: 1) whether delayed...

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Bibliographic Details
Main Authors: Jun Mu, Robert P. Ostrowski, Yoshiteru Soejima, William B. Rolland, Paul R. Krafft, Jiping Tang, John H. Zhang
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Hyperbaric oxygen therapy
CREB
PP1γ
Ubiquitination
Phosphorylation
MCAo
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611200366X

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