Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective

Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is usually diagnosed at an advanced stage when curative surgery is no longer an option. Robust diagnostic biomarkers with high sensitivity and specificity for early detection are urgently needed. Systems biology provides a powerful...

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Main Authors: Wu-Hu Zhang, Wen-Quan Wang, Xuan Han, He-Li Gao, Tian-Jiao Li, Shuai-Shuai Xu, Shuo Li, Hua-Xiang Xu, Hao Li, Long-Yun Ye, Xuan Lin, Chun-Tao Wu, Jiang Long, Xian-Jun Yu, Liang Liu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Pancreatic ductal adenocarcinoma
Systems biology
Genomics
Transcriptomics
Proteomics
Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020304852
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collection DOAJ
language English
format Article
sources DOAJ
author Wu-Hu Zhang
Wen-Quan Wang
Xuan Han
He-Li Gao
Tian-Jiao Li
Shuai-Shuai Xu
Shuo Li
Hua-Xiang Xu
Hao Li
Long-Yun Ye
Xuan Lin
Chun-Tao Wu
Jiang Long
Xian-Jun Yu
Liang Liu
spellingShingle Wu-Hu Zhang
Wen-Quan Wang
Xuan Han
He-Li Gao
Tian-Jiao Li
Shuai-Shuai Xu
Shuo Li
Hua-Xiang Xu
Hao Li
Long-Yun Ye
Xuan Lin
Chun-Tao Wu
Jiang Long
Xian-Jun Yu
Liang Liu
Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
Computational and Structural Biotechnology Journal
Pancreatic ductal adenocarcinoma
Systems biology
Genomics
Transcriptomics
Proteomics
Bioinformatics
author_facet Wu-Hu Zhang
Wen-Quan Wang
Xuan Han
He-Li Gao
Tian-Jiao Li
Shuai-Shuai Xu
Shuo Li
Hua-Xiang Xu
Hao Li
Long-Yun Ye
Xuan Lin
Chun-Tao Wu
Jiang Long
Xian-Jun Yu
Liang Liu
author_sort Wu-Hu Zhang
title Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
title_short Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
title_full Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
title_fullStr Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
title_full_unstemmed Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
title_sort advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: a systems biology perspective
publisher Elsevier
series Computational and Structural Biotechnology Journal
issn 2001-0370
publishDate 2020-01-01
description Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is usually diagnosed at an advanced stage when curative surgery is no longer an option. Robust diagnostic biomarkers with high sensitivity and specificity for early detection are urgently needed. Systems biology provides a powerful tool for understanding diseases and solving challenging biological problems, allowing biomarkers to be identified and quantified with increasing accuracy, sensitivity, and comprehensiveness. Here, we present a comprehensive overview of efforts to identify biomarkers of PDAC using genomics, transcriptomics, proteomics, metabonomics, and bioinformatics. Systems biology perspective provides a crucial “network” to integrate multi-omics approaches to biomarker identification, shedding additional light on early PDAC detection.
topic Pancreatic ductal adenocarcinoma
Systems biology
Genomics
Transcriptomics
Proteomics
Bioinformatics
url http://www.sciencedirect.com/science/article/pii/S2001037020304852
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spelling doaj-d6880b4170d44e12b3a42ab9af4640b12021-01-02T05:09:20ZengElsevierComputational and Structural Biotechnology Journal2001-03702020-01-011836063614Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspectiveWu-Hu Zhang0Wen-Quan Wang1Xuan Han2He-Li Gao3Tian-Jiao Li4Shuai-Shuai Xu5Shuo Li6Hua-Xiang Xu7Hao Li8Long-Yun Ye9Xuan Lin10Chun-Tao Wu11Jiang Long12Xian-Jun Yu13Liang Liu14Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China; Corresponding authors at: Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Pancreatic Cancer Institute, Pancreatic Cancer Institute, Fudan University, 270 Dong An Road, Shanghai 200032, China.Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China; Corresponding authors at: Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Pancreatic Cancer Institute, Pancreatic Cancer Institute, Fudan University, 270 Dong An Road, Shanghai 200032, China.Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China; Corresponding authors at: Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Pancreatic Cancer Institute, Pancreatic Cancer Institute, Fudan University, 270 Dong An Road, Shanghai 200032, China.Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is usually diagnosed at an advanced stage when curative surgery is no longer an option. Robust diagnostic biomarkers with high sensitivity and specificity for early detection are urgently needed. Systems biology provides a powerful tool for understanding diseases and solving challenging biological problems, allowing biomarkers to be identified and quantified with increasing accuracy, sensitivity, and comprehensiveness. Here, we present a comprehensive overview of efforts to identify biomarkers of PDAC using genomics, transcriptomics, proteomics, metabonomics, and bioinformatics. Systems biology perspective provides a crucial “network” to integrate multi-omics approaches to biomarker identification, shedding additional light on early PDAC detection.http://www.sciencedirect.com/science/article/pii/S2001037020304852Pancreatic ductal adenocarcinomaSystems biologyGenomicsTranscriptomicsProteomicsBioinformatics

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