The Roles of Immune Cells in the Pathogenesis of Fibrosis

Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the dif...

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Main Authors:	Enyu Huang, Na Peng, Fan Xiao, Dajun Hu, Xiaohui Wang, Liwei Lu
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	International Journal of Molecular Sciences
Subjects:	fibrosis innate immune cells adaptive immune cells myofibroblast molecular mechanism
Online Access:	https://www.mdpi.com/1422-0067/21/15/5203

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spelling	doaj-d68498b962114b42b6a075990bb3b1852020-11-25T02:56:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-01215203520310.3390/ijms21155203The Roles of Immune Cells in the Pathogenesis of FibrosisEnyu Huang0Na Peng1Fan Xiao2Dajun Hu3Xiaohui Wang4Liwei Lu5Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, ChinaDepartment of Rheumatology and Immunology, the Second People’s Hospital of Three Gorges University, Yichang 443000 ChinaDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, ChinaDepartment of Rheumatology and Immunology, the Second People’s Hospital of Three Gorges University, Yichang 443000 ChinaDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, ChinaDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, ChinaTissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.https://www.mdpi.com/1422-0067/21/15/5203fibrosisinnate immune cellsadaptive immune cellsmyofibroblastmolecular mechanism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Enyu Huang Na Peng Fan Xiao Dajun Hu Xiaohui Wang Liwei Lu
spellingShingle	Enyu Huang Na Peng Fan Xiao Dajun Hu Xiaohui Wang Liwei Lu The Roles of Immune Cells in the Pathogenesis of Fibrosis International Journal of Molecular Sciences fibrosis innate immune cells adaptive immune cells myofibroblast molecular mechanism
author_facet	Enyu Huang Na Peng Fan Xiao Dajun Hu Xiaohui Wang Liwei Lu
author_sort	Enyu Huang
title	The Roles of Immune Cells in the Pathogenesis of Fibrosis
title_short	The Roles of Immune Cells in the Pathogenesis of Fibrosis
title_full	The Roles of Immune Cells in the Pathogenesis of Fibrosis
title_fullStr	The Roles of Immune Cells in the Pathogenesis of Fibrosis
title_full_unstemmed	The Roles of Immune Cells in the Pathogenesis of Fibrosis
title_sort	roles of immune cells in the pathogenesis of fibrosis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1661-6596 1422-0067
publishDate	2020-07-01
description	Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.
topic	fibrosis innate immune cells adaptive immune cells myofibroblast molecular mechanism
url	https://www.mdpi.com/1422-0067/21/15/5203
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The Roles of Immune Cells in the Pathogenesis of Fibrosis

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