PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

DJ-1 has recently been shown to be responsible for onset of familial Parkinson’s disease (PD), PARK7. DJ-1 has been shown to play roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to trigger onset of PD. In this study, a recombinant DJ-1 protein was a...

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Bibliographic Details
Main Authors: Masatoshi Inden, Takahiro Taira, Yoshihisa Kitamura, Takashi Yanagida, Daiju Tsuchiya, Kazuyuki Takata, Daijiro Yanagisawa, Kaneyasu Nishimura, Takashi Taniguchi, Yoshiaki Kiso, Kanji Yoshimoto, Tomohiro Agatsuma, Shizuyo Koide-Yoshida, Sanae M.M. Iguchi-Ariga, Shun Shimohama, Hiroyoshi Ariga
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Neurobiology of Disease
Subjects:
DJ-1
Parkinson’s disease
Oxidative stress
Cell death
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001422

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http://www.sciencedirect.com/science/article/pii/S0969996106001422

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