Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities

A greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives. This is a new approach for the functionalization of isoxazolidine and isoxazoline derivatives to modif...

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Main Authors:	Bhaskar Chakraborty, Esmita Chettri
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Results in Chemistry
Subjects:	Mechanochemistry Sonogashira reaction Isoxazolidine Isoxazoline New heterocycles Green chemistry
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715620300151

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record_format	Article
spelling	doaj-d67b36dfabb84c12bc204b6ebd5626bd2020-12-29T04:14:10ZengElsevierResults in Chemistry2211-71562020-01-012100037Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activitiesBhaskar Chakraborty0Esmita Chettri1Organic Chemistry Laboratory, Sikkim Government College (NBBDC), Gangtok, Sikkim 737102, India; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, Wales, UK; Corresponding author at: Organic Chemistry Laboratory, Sikkim Government College (NBBDC), Gangtok, Sikkim 737102, India.Organic Chemistry Laboratory, Sikkim Government College (NBBDC), Gangtok, Sikkim 737102, IndiaA greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives. This is a new approach for the functionalization of isoxazolidine and isoxazoline derivatives to modified heterocycles via cross-coupling reaction in solvent free ball-milling process. Since this kind of functionalization of cycloadducts to modified heterocycles via cross-coupling reaction are not known in literature, therefore, this approach will surely attract synthetic chemists to plan for this kind of reactions in organic synthesis. Significant anticancer activity of the new molecules added extra flavour in this synthesis. Simple reaction methodology, good to excellent yields and greener approaches are the important features noticed in this syntheses.http://www.sciencedirect.com/science/article/pii/S2211715620300151MechanochemistrySonogashira reactionIsoxazolidineIsoxazolineNew heterocyclesGreen chemistry
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bhaskar Chakraborty Esmita Chettri
spellingShingle	Bhaskar Chakraborty Esmita Chettri Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities Results in Chemistry Mechanochemistry Sonogashira reaction Isoxazolidine Isoxazoline New heterocycles Green chemistry
author_facet	Bhaskar Chakraborty Esmita Chettri
author_sort	Bhaskar Chakraborty
title	Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities
title_short	Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities
title_full	Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities
title_fullStr	Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities
title_full_unstemmed	Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities
title_sort	mechanochemical synthesis of some heterocyclic molecules using sonogashira cross-coupling reaction and their anticancer activities
publisher	Elsevier
series	Results in Chemistry
issn	2211-7156
publishDate	2020-01-01
description	A greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives. This is a new approach for the functionalization of isoxazolidine and isoxazoline derivatives to modified heterocycles via cross-coupling reaction in solvent free ball-milling process. Since this kind of functionalization of cycloadducts to modified heterocycles via cross-coupling reaction are not known in literature, therefore, this approach will surely attract synthetic chemists to plan for this kind of reactions in organic synthesis. Significant anticancer activity of the new molecules added extra flavour in this synthesis. Simple reaction methodology, good to excellent yields and greener approaches are the important features noticed in this syntheses.
topic	Mechanochemistry Sonogashira reaction Isoxazolidine Isoxazoline New heterocycles Green chemistry
url	http://www.sciencedirect.com/science/article/pii/S2211715620300151
work_keys_str_mv	AT bhaskarchakraborty mechanochemicalsynthesisofsomeheterocyclicmoleculesusingsonogashiracrosscouplingreactionandtheiranticanceractivities AT esmitachettri mechanochemicalsynthesisofsomeheterocyclicmoleculesusingsonogashiracrosscouplingreactionandtheiranticanceractivities
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Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities

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