Scalable and DiI-compatible optical clearance of the mammalian brain

Scalable and DiI-compatible optical clearance of the mammalian brain

Efficient optical clearance is fundamental for whole brain imaging. In particular, clearance of the brain without membrane damage is required for the imaging of lipophilic tracer-labeled neural tracts. Relying on an ascending gradient of fructose solutions, SeeDB can achieve sufficient transparency...

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Bibliographic Details
Main Authors: Bing eHou, Dan eZhang, Shan eZhao, Mengping eWei, Zaifu eYang, Shaoxia eWang, Jiarui eWang, Xin eZhang, Bing eLiu, Lingzhong eFan, Yang eLi, Zilong eQiu, Chen eZhang, Tianzi eJiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Neuroanatomy
Subjects:
Urea
whole brain imaging
tract tracing
CLARITY
Cubic
Optical tissue clearing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00019/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00019/full

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