Molecular landscape in acute myeloid leukemia: where do we stand in 2016

Molecular landscape in acute myeloid leukemia: where do we stand in 2016

Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alte...

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Bibliographic Details
Main Authors: Karam Al-Issa, Aziz Nazha
Format: Article
Language:English
Published: China Anti-Cancer Association 2016-12-01
Series:Cancer Biology & Medicine
Subjects:
Acute myeloid leukemia
molecular landscape
somatic mutations
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/985
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spelling doaj-d667907d075941e89b159816399d636c2020-11-25T01:18:27ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412016-12-0113447448210.20892/j.issn.2095-3941.2016.00612016000061Molecular landscape in acute myeloid leukemia: where do we stand in 2016Karam Al-Issa0Aziz Nazha1Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland 44195, OH, USALeukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland 44195, OH, USAAcute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome.http://www.cancerbiomed.org/index.php/cocr/article/view/985Acute myeloid leukemiamolecular landscapesomatic mutations
collection DOAJ
language English
format Article
sources DOAJ
author Karam Al-Issa
Aziz Nazha
spellingShingle Karam Al-Issa
Aziz Nazha
Molecular landscape in acute myeloid leukemia: where do we stand in 2016
Cancer Biology & Medicine
Acute myeloid leukemia
molecular landscape
somatic mutations
author_facet Karam Al-Issa
Aziz Nazha
author_sort Karam Al-Issa
title Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_short Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_full Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_fullStr Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_full_unstemmed Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_sort molecular landscape in acute myeloid leukemia: where do we stand in 2016
publisher China Anti-Cancer Association
series Cancer Biology & Medicine
issn 2095-3941
2095-3941
publishDate 2016-12-01
description Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome.
topic Acute myeloid leukemia
molecular landscape
somatic mutations
url http://www.cancerbiomed.org/index.php/cocr/article/view/985
work_keys_str_mv AT karamalissa molecularlandscapeinacutemyeloidleukemiawheredowestandin2016
AT aziznazha molecularlandscapeinacutemyeloidleukemiawheredowestandin2016
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