Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii

Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii

Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B (1 and 2). A third macrocyclic compound, unna...

Full description

Bibliographic Details
Main Authors:	Matthew J. Bertin, Alexandre F. Roduit, Jiadong Sun, Gabriella E. Alves, Christopher W. Via, Miguel A. Gonzalez, Paul V. Zimba, Peter D. R. Moeller
Format:	Article
Language:	English
Published:	MDPI AG 2017-06-01
Series:	Marine Drugs
Subjects:	Trichodesmium thiebautii macrocycle depsipeptide cyanobacteria
Online Access:	http://www.mdpi.com/1660-3397/15/7/206

Similar Items

Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom
by: Matthew J. Bertin, et al.
Published: (2017-01-01)

Desert Dust as a Source of Iron to the Globally Important Diazotroph Trichodesmium
by: Despo Polyviou, et al.
Published: (2018-01-01)

First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
by: Dominique Laurent, et al.
Published: (2011-03-01)

Regulation of Trichodesmium Nitrogen Fixation by Combined Nitrogen and Growth Rate: A Field and Culture Study
by: Holl, Carolyn Marie
Published: (2005)

Offshore distribution patterns of the cyanobacterium Trichodesmium erythraeum ehrenberg and associated phyto- and bacterioplankton in the southern Atlantic coast (Paraná, Brazil)
by: Adriana Siqueira, et al.
Published: (2006-03-01)

Influence of Co and B12 on the growth and nitrogen fixation of Trichodesmium
by: Irene Barra Rodriguez, et al.
Published: (2015-06-01)

An Integrated Response of Trichodesmium erythraeum IMS101 Growth and Photo-Physiology to Iron, CO2, and Light Intensity
by: Tobias G. Boatman, et al.
Published: (2018-04-01)

Changes in Proteins Associated with Nitrogen Fixation and Iron Nutrition in the Marine Cyanobacterium Trichodesmium
by: Elardo, Karen Marie
Published: (1994)

Functional Genomics and Phylogenetic Evidence Suggest Genus-Wide Cobalamin Production by the Globally Distributed Marine Nitrogen Fixer Trichodesmium
by: Nathan G. Walworth, et al.
Published: (2018-02-01)

Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria
by: Danmeng Luo, et al.
Published: (2019-02-01)

Interrelated influence of light and Ni on Trichodesmium growth
by: Tung-Yuan eHo, et al.
Published: (2013-05-01)

Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
by: Synthia Michon, et al.
Published: (2021-01-01)

Physiological ecology of Trichodesmium and its microbiome in the oligotrophic ocean
by: Frischkorn, Kyle Robert
Published: (2018)

Screening the toxicity and toxin content of blooms of the cyanobacterium Trichodesmium erythraeum (Ehrenberg) in northeast Brasil
by: LAO Proença, et al.
Published: (2009-01-01)

The unique biogeochemical signature of the marine diazotroph Trichodesmium
by: Jochen eNuester, et al.
Published: (2012-04-01)

Spatial and seasonal variations of Cyanobacteria and their nitrogen fixation rates in Sanya Bay, South China Sea
by: Junde Dong, et al.
Published: (2008-06-01)

A new species of Trichodesmium (Cyanobacteria) from freshwaters, Brazil
by: Célia L. Sant'Anna, et al.

Anti-Chikungunya Viral Activities of Aplysiatoxin-Related Compounds from the Marine Cyanobacterium Trichodesmium erythraeum
by: Deepak Kumar Gupta, et al.
Published: (2014-01-01)

Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena
by: Hendrik Luesch, et al.
Published: (2009-11-01)

Temporal Variability of Trichodesmium spp. and Diatom-Diazotroph Assemblages in the North Pacific Subtropical Gyre
by: Angelicque E. White, et al.
Published: (2018-02-01)

The Metabolome of a Cyanobacterial Bloom Visualized by MS/MS-Based Molecular Networking Reveals New Neurotoxic Smenamide Analogs (C, D, and E)
by: Christopher W. Via, et al.
Published: (2018-07-01)

Microbiome of Trichodesmium Colonies from the North Pacific Subtropical Gyre
by: Mary R. Gradoville, et al.
Published: (2017-07-01)

Analysis of ferredoxin and flavodoxin in Anabaena and Trichodesmium using fast protein liquid chromatography
by: Jones, Karen Lorraine
Published: (1988)

Microplankton size structure induced by a warm-core eddy in the western Bay of Bengal: Role of Trichodesmium abundance
by: Karnan Chinnadurai, et al.
Published: (2021-07-01)

Corrigendum: Microbiome of Trichodesmium Colonies from the North Pacific Subtropical Gyre
by: Mary R. Gradoville, et al.
Published: (2017-09-01)

Hydrogen Dynamics in Trichodesmium Colonies and Their Potential Role in Mineral Iron Acquisition
by: Meri Eichner, et al.
Published: (2019-07-01)

Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
by: Sebastian Theobald, et al.
Published: (2019-11-01)

Diversity of the marine cyanobacterium Trichodesmium : characterization of the Woods Hole culture collection and quantification of field populations
by: Hynes, Annette Michelle
Published: (2010)

Distinct Responses of the Nitrogen-Fixing Marine Cyanobacterium Trichodesmium to a Thermally Variable Environment as a Function of Phosphorus Availability
by: Pingping Qu, et al.
Published: (2019-06-01)

Summer distribution patterns of Trichodesmium spp. in the Changjiang (Yangtze River) Estuary and adjacent East China Sea shelf
by: Zhibing Jiang, et al.
Published: (2017-07-01)

Structural studies of PKS and NRPS docking domains
by: Amaee, Richard Dana
Published: (2007)

Templating strategies in phosphorus macrocycle chemistry
by: Friesen, Dawn Marie.
Published: (2008)

Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
by: Xufen Yu, et al.
Published: (2013-05-01)

Chemistry of functionalised macrocycles
by: Matthes, Karen Elizabeth
Published: (1987)

Comparison of Diazotrophic Composition and Distribution in the South China Sea and the Western Pacific Ocean
by: Changling Ding, et al.
Published: (2021-06-01)

Investigations of highly conjugated macrocycles and polymers for aggregation and chemical sensing
by: Boden, Britta Nicole
Published: (2008)

Investigations of highly conjugated macrocycles and polymers for aggregation and chemical sensing
by: Boden, Britta Nicole
Published: (2008)

Investigations of highly conjugated macrocycles and polymers for aggregation and chemical sensing
by: Boden, Britta Nicole
Published: (2008)

Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions
by: Hassan Farhid, et al.
Published: (2021-06-01)

Characterization of phytoplankton biodiversity in tropical shipwrecks off the coast of Pernambuco, Brazil Caracterização da biodiversidade do fitoplâncton em naufrágios tropicais da costa de Pernambuco, Brasil
by: Douglas Henrique Cavalcanti dos Santos, et al.
Published: (2010-12-01)