EFECTO ANTINOCICEPTIVO DEL EXTRACTO ETANÓLICO DE LAS HOJAS DE MAYTENUS MACROCARPA (RUIZ & PAV.) BRIQ. “CHUCHUHUASI” MEDIANTE LA PRUEBA DE CONTORSIONES ABDOMINALES EN RATONES.

• Main Authors: V Robles-Pizarro, L Tarqui-Cabrera, N Rodríguez-Collazos, A Morales-Chau, J De La Cruz-Manyari, K Ríos-Melgar, D Rivera-Cruzado, A Rubio-Gonzáles, C Santa Cruz-Contreras, G Velazco-Curay, B Loja-Herrera, A Alvarado-Yarasca, B Castañeda-Castañeda, A Salazar-Granara
• Format: Article
• Language: Spanish
• Published: Universidad de San Martín de Porres 2014-01-01
• Series: Horizonte Médico
• Subjects: Maytenus macrocarpa leaves; writhing pain; Traditional Medicine; Medicinal Plants; eded
• Online Access: http://www.horizontemedicina.usmp.edu.pe/index.php/horizontemed/article/view/44/42
• ISSN: 1727-558X; 2227-3530

ABSTRACT Objective: To determine the effect and antinociceptive activity of the leaves of Maytenus macrocarpa (Ruiz & Pav ) Briq . “Chuchuhuasi “ by the writhing test in rodents. Material and Methods: 40 male albino mice were used, with average weights of 25g , the writhing test was used to determine the antinociceptive activity . The experimental groups were: Control; received no substance, ethanol extract of the leaves of M. macrocarpa Briq (Ruiz & Pav.) 2000 mg/kg, Tramadol 10 mg/kg and 10mg Sodium Diclofenac /kg. The substances were administered orally one hour before the induction of pain. For statistical validation the Shapiro -Wilk test, one-tailed ANOVA, Tukey, and Newman -Keuls was used. Results: Writhing number was 41 +/- 3.04, 27 +/- 3.55, 9 +/- 4.14, and 18 +/- 2.65 respectively. The inhibition percentage of the nociceptive behavior was: 0%, 34%, 77% and 55%. The test of one-way ANOVA showed statistical differences (p < 0.05, 95% CI), and the Tukey and Newman-Keuls test showed significant differences between groups versus control. Conclusion: Antinociceptive effect of the leaves of Maytenus macrocarpa (Ruiz & Pav.) Briq “Chuchuhuasi “ was found at doses of 2000 mg/kg. (Horiz Med 2013; 13(4): 6-10)