Structural and functional characterization of the bacterial biofilm activator RemA

Structural and functional characterization of the bacterial biofilm activator RemA

Biofilm formation in Bacillus subtilis requires expression of matrix production genes, which are upregulated by transcriptional activator RemA. Here, the authors show that RemA forms octameric rings with the potential to form a 16-meric superstructure, suggesting that the protein can wrap DNA throug...

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Main Authors: Tamara Hoffmann, Devid Mrusek, Patricia Bedrunka, Fabiana Burchert, Christopher-Nils Mais, Daniel B. Kearns, Florian Altegoer, Erhard Bremer, Gert Bange
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26005-4
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spelling doaj-d65f8dc8c4264fadb72b501cc705fb6e2021-10-03T11:49:33ZengNature Publishing GroupNature Communications2041-17232021-09-0112111110.1038/s41467-021-26005-4Structural and functional characterization of the bacterial biofilm activator RemATamara Hoffmann0Devid Mrusek1Patricia Bedrunka2Fabiana Burchert3Christopher-Nils Mais4Daniel B. Kearns5Florian Altegoer6Erhard Bremer7Gert Bange8Philipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of BiologyPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of ChemistryPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of ChemistryPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of ChemistryPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of ChemistryDepartment of Biology, Indiana UniversityPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of ChemistryPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of BiologyPhilipps-University Marburg, Center for Synthetic Microbiology (SYNMIKRO) & Faculty of ChemistryBiofilm formation in Bacillus subtilis requires expression of matrix production genes, which are upregulated by transcriptional activator RemA. Here, the authors show that RemA forms octameric rings with the potential to form a 16-meric superstructure, suggesting that the protein can wrap DNA through a LytTR-related domain.https://doi.org/10.1038/s41467-021-26005-4
collection DOAJ
language English
format Article
sources DOAJ
author Tamara Hoffmann
Devid Mrusek
Patricia Bedrunka
Fabiana Burchert
Christopher-Nils Mais
Daniel B. Kearns
Florian Altegoer
Erhard Bremer
Gert Bange
spellingShingle Tamara Hoffmann
Devid Mrusek
Patricia Bedrunka
Fabiana Burchert
Christopher-Nils Mais
Daniel B. Kearns
Florian Altegoer
Erhard Bremer
Gert Bange
Structural and functional characterization of the bacterial biofilm activator RemA
Nature Communications
author_facet Tamara Hoffmann
Devid Mrusek
Patricia Bedrunka
Fabiana Burchert
Christopher-Nils Mais
Daniel B. Kearns
Florian Altegoer
Erhard Bremer
Gert Bange
author_sort Tamara Hoffmann
title Structural and functional characterization of the bacterial biofilm activator RemA
title_short Structural and functional characterization of the bacterial biofilm activator RemA
title_full Structural and functional characterization of the bacterial biofilm activator RemA
title_fullStr Structural and functional characterization of the bacterial biofilm activator RemA
title_full_unstemmed Structural and functional characterization of the bacterial biofilm activator RemA
title_sort structural and functional characterization of the bacterial biofilm activator rema
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Biofilm formation in Bacillus subtilis requires expression of matrix production genes, which are upregulated by transcriptional activator RemA. Here, the authors show that RemA forms octameric rings with the potential to form a 16-meric superstructure, suggesting that the protein can wrap DNA through a LytTR-related domain.
url https://doi.org/10.1038/s41467-021-26005-4
work_keys_str_mv AT tamarahoffmann structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT devidmrusek structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT patriciabedrunka structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT fabianaburchert structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT christophernilsmais structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT danielbkearns structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT florianaltegoer structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT erhardbremer structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
AT gertbange structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
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