Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice

Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice

Despite the increasing use of humanized mouse models to study new approaches of graft-versus-host disease (GVHD) prevention, the pathogenesis of xenogeneic GVHD (xGVHD) in these models remains misunderstood. The aim of this study is to describe this pathogenesis in NOD/LtSz-PrkdcscidIL2rγtm1Wjl (NSG...

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Bibliographic Details
Main Authors: Grégory Ehx, Joan Somja, Hans-Jörg Warnatz, Caroline Ritacco, Muriel Hannon, Loïc Delens, Gilles Fransolet, Philippe Delvenne, Joséphine Muller, Yves Beguin, Hans Lehrach, Ludovic Belle, Stéphanie Humblet-Baron, Frédéric Baron
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
GVHD
xenogeneic
NSG
NSG-HLA-A2/HHD
TCR receptor
TCRβ repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01943/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01943/full

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