αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

It is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.

Bibliographic Details
Main Authors: Chun-Ying Li, Jimmy Hu, Hongbing Lu, Jing Lan, Wei Du, Nicole Galicia, Ophir D. Klein
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12133
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spelling doaj-d64ac56e33ff4303bea39c5f99d644e92021-05-11T11:10:31ZengNature Publishing GroupNature Communications2041-17232016-07-017111310.1038/ncomms12133αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth developmentChun-Ying Li0Jimmy Hu1Hongbing Lu2Jing Lan3Wei Du4Nicole Galicia5Ophir D. Klein6The Research Center and Department of Pathology, Zhongshan Hospital of Dalian UniversityDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of CaliforniaDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of CaliforniaDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of CaliforniaDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of CaliforniaDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of CaliforniaDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of CaliforniaIt is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.https://doi.org/10.1038/ncomms12133
collection DOAJ
language English
format Article
sources DOAJ
author Chun-Ying Li
Jimmy Hu
Hongbing Lu
Jing Lan
Wei Du
Nicole Galicia
Ophir D. Klein
spellingShingle Chun-Ying Li
Jimmy Hu
Hongbing Lu
Jing Lan
Wei Du
Nicole Galicia
Ophir D. Klein
αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
Nature Communications
author_facet Chun-Ying Li
Jimmy Hu
Hongbing Lu
Jing Lan
Wei Du
Nicole Galicia
Ophir D. Klein
author_sort Chun-Ying Li
title αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_short αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_full αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_fullStr αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_full_unstemmed αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_sort αe-catenin inhibits yap/taz activity to regulate signalling centre formation during tooth development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-07-01
description It is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.
url https://doi.org/10.1038/ncomms12133
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AT jinglan aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment
AT weidu aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment
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