Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.

Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.

The 5'untranslated regions (UTR) of the full length mRNA of the HIV-1 proviral clones pNL4.3 and pLAI, harbor an internal ribosomal entry site (IRES). In this study we extend this finding by demonstrating that the mRNA 5'UTRs of natural variants of HIV-1 also exhibit IRES-activity. Cap-ind...

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Bibliographic Details
Main Authors: Maricarmen Vallejos, Felipe Carvajal, Karla Pino, Camilo Navarrete, Marcela Ferres, Juan Pablo Huidobro-Toro, Bruno Sargueil, Marcelo López-Lastra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3319624?pdf=render

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