ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.

Bibliographic Details
Main Authors: Yusuke Shiromoto, Masayuki Sakurai, Moeko Minakuchi, Kentaro Ariyoshi, Kazuko Nishikura
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21921-x
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spelling doaj-d62b10b4d1d74942aebc54b86dd22af02021-03-14T12:07:15ZengNature Publishing GroupNature Communications2041-17232021-03-0112111810.1038/s41467-021-21921-xADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cellsYusuke Shiromoto0Masayuki Sakurai1Moeko Minakuchi2Kentaro Ariyoshi3Kazuko Nishikura4The Wistar InstituteThe Wistar InstituteThe Wistar InstituteThe Wistar InstituteThe Wistar InstituteOne type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.https://doi.org/10.1038/s41467-021-21921-x
collection DOAJ
language English
format Article
sources DOAJ
author Yusuke Shiromoto
Masayuki Sakurai
Moeko Minakuchi
Kentaro Ariyoshi
Kazuko Nishikura
spellingShingle Yusuke Shiromoto
Masayuki Sakurai
Moeko Minakuchi
Kentaro Ariyoshi
Kazuko Nishikura
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
Nature Communications
author_facet Yusuke Shiromoto
Masayuki Sakurai
Moeko Minakuchi
Kentaro Ariyoshi
Kazuko Nishikura
author_sort Yusuke Shiromoto
title ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_short ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_full ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_fullStr ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_full_unstemmed ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_sort adar1 rna editing enzyme regulates r-loop formation and genome stability at telomeres in cancer cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.
url https://doi.org/10.1038/s41467-021-21921-x
work_keys_str_mv AT yusukeshiromoto adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells
AT masayukisakurai adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells
AT moekominakuchi adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells
AT kentaroariyoshi adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells
AT kazukonishikura adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells
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