Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life

Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life

Brain inflammation in early life has been proposed to play important roles in the development of neurodegenerative disorders in adult life. To test this hypothesis, we used a neonatal rat model of lipopolysaccharide (LPS) exposure (1000 EU/g body weight, intracerebral injection on P5) to produce bra...

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Bibliographic Details
Main Authors: Lir-Wan Fan, Lu-Tai Tien, Rick C.S. Lin, Kimberly L. Simpson, Philip G. Rhodes, Zhengwei Cai
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Neurobiology of Disease
Subjects:
Lipopolysaccharide
Neurodegenerative disorder
Substantia nigra
Tyrosine hydroxylase
Rotenone
Axonal impairment
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002373

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