Role of Energy Metabolic Deficits and Oxidative Stress in Excitotoxic Spinal Motor Neuron Degeneration
MN (motor neuron) death in amyotrophic lateral sclerosis may be mediated by glutamatergic excitotoxicity. Previously, our group showed that the microdialysis perfusion of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) in the rat lumbar spinal cord induced MN death and permanent paralysis w...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-02-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1042/AN20130046 |