Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination

Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination

Protein citrullination catalyzed by peptidyl arginine deiminase (PADs) is involved in autoimmune disease pathogenesis, especially in rheumatoid arthritis. Calcium is a key regulator of PAD activity, but under normal physiological conditions it remains uncertain how intracellular calcium levels can b...

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Bibliographic Details
Main Authors: Yebin Zhou, Nanette Mittereder, Gary P. Sims
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
neutrophil
citrullination
bicarbonate
PAD2
PAD4
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00034/full

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