Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.

Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.

The CPCRA 064 study examined the effect of structured treatment interruption (STI) of up to 4 months followed by salvage treatment in patients failing therapy with multi-drug resistant HIV. We examined the relationship between the reversion rate of major reverse transcriptase (RT) resistance-associa...

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Bibliographic Details
Main Authors: Agnes C Paquet, John Baxter, Jodi Weidler, Yolanda Lie, Jody Lawrence, Rose Kim, Michael Bates, Eoin Coakley, Colombe Chappey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031504?pdf=render

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