Safranal epoxide – A potential source for diverse therapeutic applications

Safranal epoxide – A potential source for diverse therapeutic applications

Safranal is an organic compound isolated from saffron oil. Photo epoxidation and thermal reactions of safranal can be a significant tool for the design of drugs to act as anticancer agents and potent chemoprevention. Safranal was subjected to oxidation reactions either thermally using m-chloroperben...

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Main Authors: Suzan Khayyat, Eman Elgendy
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Saudi Pharmaceutical Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016417301706
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spelling doaj-d5fdc054f6204f1fac9a87622e6802e92020-11-24T22:54:32ZengElsevierSaudi Pharmaceutical Journal1319-01642018-01-01261115119Safranal epoxide – A potential source for diverse therapeutic applicationsSuzan Khayyat0Eman Elgendy1Chemistry Depatment, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Corresponding author.Faculty of Specific Education, Mansoura University, Mansoura, EgyptSafranal is an organic compound isolated from saffron oil. Photo epoxidation and thermal reactions of safranal can be a significant tool for the design of drugs to act as anticancer agents and potent chemoprevention. Safranal was subjected to oxidation reactions either thermally using m-chloroperbenzoic acid or photochemically with hydrogen peroxide. Photo chemically and thermally oxidation reaction gave the corresponding monoepoxy together with diepoxy derivatives. The primary tested of epoxide derivatives showed a moderate degree of DNA alkylation. Studies on the antimicrobial, especially Methicillin resistant Staphylococcus aureus (MRSA), showed high activity of safranal diepoxide (3) against the growth of bacteria Methicillin resistant Staphylococcus aureus (MRSA) more than safranal (1) and monoepoxide (2) respectively.The epoxidation products were tested against bacterium Methicillin resistant Staphylococcus aureus (MRSA). Keywords: Thermal, Photo epoxidation, Safranal, m-Chloloperbenzoic acid, Monoterpene, Staphylococcus aureushttp://www.sciencedirect.com/science/article/pii/S1319016417301706
collection DOAJ
language English
format Article
sources DOAJ
author Suzan Khayyat
Eman Elgendy
spellingShingle Suzan Khayyat
Eman Elgendy
Safranal epoxide – A potential source for diverse therapeutic applications
Saudi Pharmaceutical Journal
author_facet Suzan Khayyat
Eman Elgendy
author_sort Suzan Khayyat
title Safranal epoxide – A potential source for diverse therapeutic applications
title_short Safranal epoxide – A potential source for diverse therapeutic applications
title_full Safranal epoxide – A potential source for diverse therapeutic applications
title_fullStr Safranal epoxide – A potential source for diverse therapeutic applications
title_full_unstemmed Safranal epoxide – A potential source for diverse therapeutic applications
title_sort safranal epoxide – a potential source for diverse therapeutic applications
publisher Elsevier
series Saudi Pharmaceutical Journal
issn 1319-0164
publishDate 2018-01-01
description Safranal is an organic compound isolated from saffron oil. Photo epoxidation and thermal reactions of safranal can be a significant tool for the design of drugs to act as anticancer agents and potent chemoprevention. Safranal was subjected to oxidation reactions either thermally using m-chloroperbenzoic acid or photochemically with hydrogen peroxide. Photo chemically and thermally oxidation reaction gave the corresponding monoepoxy together with diepoxy derivatives. The primary tested of epoxide derivatives showed a moderate degree of DNA alkylation. Studies on the antimicrobial, especially Methicillin resistant Staphylococcus aureus (MRSA), showed high activity of safranal diepoxide (3) against the growth of bacteria Methicillin resistant Staphylococcus aureus (MRSA) more than safranal (1) and monoepoxide (2) respectively.The epoxidation products were tested against bacterium Methicillin resistant Staphylococcus aureus (MRSA). Keywords: Thermal, Photo epoxidation, Safranal, m-Chloloperbenzoic acid, Monoterpene, Staphylococcus aureus
url http://www.sciencedirect.com/science/article/pii/S1319016417301706
work_keys_str_mv AT suzankhayyat safranalepoxideapotentialsourcefordiversetherapeuticapplications
AT emanelgendy safranalepoxideapotentialsourcefordiversetherapeuticapplications
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