Opa1 is required for proper mitochondrial metabolism in early development.

Opa1 is required for proper mitochondrial metabolism in early development.

Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicating that OPA1 is essential for embryonic development. Zebrafis...

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Bibliographic Details
Main Authors: Jennifer J Rahn, Krista D Stackley, Sherine S L Chan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597633?pdf=render

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