Tailored Therapy in Lung Cancer

Tailored Therapy in Lung Cancer

Historically, all non-small cell lung cancers were essentially grouped together and considered to be a single disease. However, it is now recognized that non-small cell lung cancer actually comprises a genetically diverse group of tumours. This, in turn, affords a new opportunity for the development...

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Main Authors: George Rakovich, Lise Tremblay
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Canadian Respiratory Journal
Online Access:http://dx.doi.org/10.1155/2013/506383
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spelling doaj-d5fbb51b076442f1b13b107a1ff5cd432021-07-02T01:40:52ZengHindawi LimitedCanadian Respiratory Journal1198-22412013-01-0120536736810.1155/2013/506383Tailored Therapy in Lung CancerGeorge Rakovich0Lise Tremblay1Division of Thoracic Surgery, Hôpital Maisonneuve Rosemont, University of Montreal, Montreal, CanadaDivision of Respirology, Institut Universitaire de Cardiologie et de Pneumologie de Québec – Laval University, Quebec City, Quebec, CanadaHistorically, all non-small cell lung cancers were essentially grouped together and considered to be a single disease. However, it is now recognized that non-small cell lung cancer actually comprises a genetically diverse group of tumours. This, in turn, affords a new opportunity for the development of effective treatments tailored to individual tumours and patients. Advances in molecular biology have made possible the development of drugs against specific molecular targets on cancer cells, most notably the tyrosine kinase inhibitors. The relevant literature and current practice guidelines are discussed. In addition, other related areas of active investigation, including tumour vaccines and pharmacogenetics, are briefly reviewed.http://dx.doi.org/10.1155/2013/506383
collection DOAJ
language English
format Article
sources DOAJ
author George Rakovich
Lise Tremblay
spellingShingle George Rakovich
Lise Tremblay
Tailored Therapy in Lung Cancer
Canadian Respiratory Journal
author_facet George Rakovich
Lise Tremblay
author_sort George Rakovich
title Tailored Therapy in Lung Cancer
title_short Tailored Therapy in Lung Cancer
title_full Tailored Therapy in Lung Cancer
title_fullStr Tailored Therapy in Lung Cancer
title_full_unstemmed Tailored Therapy in Lung Cancer
title_sort tailored therapy in lung cancer
publisher Hindawi Limited
series Canadian Respiratory Journal
issn 1198-2241
publishDate 2013-01-01
description Historically, all non-small cell lung cancers were essentially grouped together and considered to be a single disease. However, it is now recognized that non-small cell lung cancer actually comprises a genetically diverse group of tumours. This, in turn, affords a new opportunity for the development of effective treatments tailored to individual tumours and patients. Advances in molecular biology have made possible the development of drugs against specific molecular targets on cancer cells, most notably the tyrosine kinase inhibitors. The relevant literature and current practice guidelines are discussed. In addition, other related areas of active investigation, including tumour vaccines and pharmacogenetics, are briefly reviewed.
url http://dx.doi.org/10.1155/2013/506383
work_keys_str_mv AT georgerakovich tailoredtherapyinlungcancer
AT lisetremblay tailoredtherapyinlungcancer
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