Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

Metastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [18F]fluorodeoxyglucose positron emission tomography imaging, coupled with recent findings linking hypoxia-inducible factor (HIF-1α) overexpression to aggressive cancers, has rekindled an interest in this asp...

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Bibliographic Details
Main Authors: Ian F. Robey, Anthony D. Lien, Sarah J. Welsh, Brenda K. Baggett, Robert J. Gillies
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Warburg effect
hypoxia-inducible factor
glucose consumption
lactate
glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800636

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http://www.sciencedirect.com/science/article/pii/S1476558605800636

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