A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Abstract Background Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly...

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Bibliographic Details
Main Authors: Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried, Allan I. Levey
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Neuroinflammation
Potassium channels
Kv1.3
Proteomics
Online Access:http://link.springer.com/article/10.1186/s12974-017-0906-6

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