Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery

Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery

Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have s...

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Bibliographic Details
Main Authors: Alexander A. Braddock, Emmanuel A. Theodorakis
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Marine Drugs
Subjects:
natural product
spirotetronate
antibiotic
anticancer
drug resistance
Diels-Alder
Diels-Alderase
biosynthesis
total synthesis
Bcl-2 inhibitor
pABA inhibitor
UPR apoptosis
Online Access:https://www.mdpi.com/1660-3397/17/4/232

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https://www.mdpi.com/1660-3397/17/4/232

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