Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects

Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects

Abnormal development of central nervous system (CNS) caused by neural tube defects (NTDs) is not only remained the major contributor in the prevalence of stillbirths and neonatal deaths, but also represents a significant cause of lifelong physical disability in the surviving infants. Ethionine is a...

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Bibliographic Details
Main Authors: Li Zhang, Yanting Dong, Wenzhuo Wang, Taoran Zhao, Tingjuan Huang, Ajab Khan, Lei Wang, Zhizhen Liu, Jun Xie, Bo Niu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neurology
Subjects:
ethionine
neural tube defects
reactive oxygen species
mitochondrial membrane potential
mitochondria autophagy
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00242/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.00242/full

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