Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer

Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer

The intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lysophosphatidic acid (LPA) and its receptors in the g...

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Bibliographic Details
Main Author: C. Chris Yun
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
lysophosphatidic acid
colorectal cancer
inflammation
intestine
Online Access:https://www.mdpi.com/2072-6694/11/7/958
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spelling doaj-d5e3a9329b054d27b817cb74e4dd608c2020-11-25T00:29:17ZengMDPI AGCancers2072-66942019-07-0111795810.3390/cancers11070958cancers11070958Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal CancerC. Chris Yun0Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Whitehead Research Bldg. Room 201, 615 Michael Street, Atlanta, GA 30322, USAThe intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lysophosphatidic acid (LPA) and its receptors in the gut has been progressively appreciated. LPA signaling modulates cell proliferation, invasion, adhesion, angiogenesis, and survival that can promote cancer growth and metastasis. These effects are equally important for the maintenance of the epithelial barrier in the gut, which forms the first line of defense against the milieu of potentially pathogenic stimuli. This review focuses on the LPA-mediated signaling that potentially contributes to inflammation and tumor formation in the gastrointestinal tract.https://www.mdpi.com/2072-6694/11/7/958lysophosphatidic acidcolorectal cancerinflammationintestine
collection DOAJ
language English
format Article
sources DOAJ
author C. Chris Yun
spellingShingle C. Chris Yun
Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
Cancers
lysophosphatidic acid
colorectal cancer
inflammation
intestine
author_facet C. Chris Yun
author_sort C. Chris Yun
title Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
title_short Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
title_full Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
title_fullStr Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
title_full_unstemmed Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
title_sort lysophosphatidic acid and autotaxin-associated effects on the initiation and progression of colorectal cancer
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2019-07-01
description The intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lysophosphatidic acid (LPA) and its receptors in the gut has been progressively appreciated. LPA signaling modulates cell proliferation, invasion, adhesion, angiogenesis, and survival that can promote cancer growth and metastasis. These effects are equally important for the maintenance of the epithelial barrier in the gut, which forms the first line of defense against the milieu of potentially pathogenic stimuli. This review focuses on the LPA-mediated signaling that potentially contributes to inflammation and tumor formation in the gastrointestinal tract.
topic lysophosphatidic acid
colorectal cancer
inflammation
intestine
url https://www.mdpi.com/2072-6694/11/7/958
work_keys_str_mv AT cchrisyun lysophosphatidicacidandautotaxinassociatedeffectsontheinitiationandprogressionofcolorectalcancer
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