Validação de método analítico por cromatografia líquida de alta eficiência para doseamento do adapaleno em suspensões de nanocápsulas

Validação de método analítico por cromatografia líquida de alta eficiência para doseamento do adapaleno em suspensões de nanocápsulas

Adapalene is a retinoid drug often used for disorders of the skin, mainly acne. In this work, an analytical method for the quantification of adapaleno in suspensions of nanocapsules by HPLC was developed and validated. The method was linear in the range of 10-30 µg mL-1, with a good correlation coef...

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Bibliographic Details
Main Authors: Jerusa Goi Barrios, Gabriela D'Avila Farias, Isabel Roggia, Sandra Cadore Peixoto, Flábio R. Pons, Márcia Bruschi, Renata Platcheck Raffin, Marta Palma Alves
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2011-01-01
Series:Química Nova
Subjects:
adapalene
validation
HPLC
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800029&lng=en&tlng=en
Description
Summary:Adapalene is a retinoid drug often used for disorders of the skin, mainly acne. In this work, an analytical method for the quantification of adapaleno in suspensions of nanocapsules by HPLC was developed and validated. The method was linear in the range of 10-30 µg mL-1, with a good correlation coefficient (r = 0.994). Precision and accuracy analysis showed low relative standard deviation (< 4.6%) and a good recovery percentual (98.2-106.9%). The procedure was specific, linear, precise, exact and robust so that the method can be applied in quantification of adapalene in suspensions of nanocapsules.
ISSN:1678-7064

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