Kinetic Analysis of Lidocaine Elimination by Pig Liver Cells Cultured in 3D Multi-Compartment Hollow Fiber Membrane Network Perfusion Bioreactors

Kinetic Analysis of Lidocaine Elimination by Pig Liver Cells Cultured in 3D Multi-Compartment Hollow Fiber Membrane Network Perfusion Bioreactors

Liver cells cultured in 3D bioreactors is an interesting option for temporary extracorporeal liver support in the treatment of acute liver failure and for animal models for preclinical drug screening. Bioreactor capacity to eliminate drugs is generally used for assessing cell metabolic competence in...

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Bibliographic Details
Main Authors: Gerardo Catapano, Juliane K. Unger, Elisabetta M. Zanetti, Gionata Fragomeni, Jörg C. Gerlach
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Bioengineering
Subjects:
adsorption
bioreactor
elimination
kinetics
lidocaine
liver cells
Online Access:https://www.mdpi.com/2306-5354/8/8/104

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