SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα and its response element within promoter regions and...

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Main Authors: Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. Hirschey, Haim Y. Cohen
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471931558X

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