Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of...

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Main Authors: Włodzimierz Łuczyński, Wojciech Fendler, Anna Ramatowska, Agnieszka Szypowska, Agnieszka Szadkowska, Wojciech Młynarski, Miron Chumiecki, Przemysława Jarosz-Chobot, Joanna Chrzanowska, Anna Noczyńska, Agnieszka Brandt, Małgorzata Myśliwiec, Barbara Głowińska-Olszewska, Paweł Bernatowicz, Oksana Kowalczuk, Artur Bossowski
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2014/630712
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spelling doaj-d5da7418c2434ada973be65fe63a6f4a2020-11-24T20:59:55ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/630712630712Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe ObesityWłodzimierz Łuczyński0Wojciech Fendler1Anna Ramatowska2Agnieszka Szypowska3Agnieszka Szadkowska4Wojciech Młynarski5Miron Chumiecki6Przemysława Jarosz-Chobot7Joanna Chrzanowska8Anna Noczyńska9Agnieszka Brandt10Małgorzata Myśliwiec11Barbara Głowińska-Olszewska12Paweł Bernatowicz13Oksana Kowalczuk14Artur Bossowski15Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, PolandDepartment of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, PolandDepartment of Paediatrics, Medical University of Warsaw, Warsaw 01-184, PolandDepartment of Paediatrics, Medical University of Warsaw, Warsaw 01-184, PolandDepartment of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, PolandDepartment of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, PolandDepartment of Paediatrics, Paediatric Endocrinology and Diabetology, Medical University of Silesia, in Katowice, Katowice 40-752, PolandDepartment of Paediatrics, Paediatric Endocrinology and Diabetology, Medical University of Silesia, in Katowice, Katowice 40-752, PolandDepartment of Endocrinology and Diabetology of Children and Adolescents, Wroclaw Medical University, Wroclaw 50-268, PolandDepartment of Endocrinology and Diabetology of Children and Adolescents, Wroclaw Medical University, Wroclaw 50-268, PolandDepartment of Paediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk 80-211, PolandDepartment of Paediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk 80-211, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, PolandDepartment of Haematology, Medical University of Bialystok, Bialystok 15-274, PolandDepartment of Clinical Molecular Biology, Medical University of Bialystok, Bialystok 15-274, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, PolandThe objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P=0.0003), poor metabolic control (P=0.0001), and carriage of the A allele of the FTO rs9939609 gene (P=0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).http://dx.doi.org/10.1155/2014/630712
collection DOAJ
language English
format Article
sources DOAJ
author Włodzimierz Łuczyński
Wojciech Fendler
Anna Ramatowska
Agnieszka Szypowska
Agnieszka Szadkowska
Wojciech Młynarski
Miron Chumiecki
Przemysława Jarosz-Chobot
Joanna Chrzanowska
Anna Noczyńska
Agnieszka Brandt
Małgorzata Myśliwiec
Barbara Głowińska-Olszewska
Paweł Bernatowicz
Oksana Kowalczuk
Artur Bossowski
spellingShingle Włodzimierz Łuczyński
Wojciech Fendler
Anna Ramatowska
Agnieszka Szypowska
Agnieszka Szadkowska
Wojciech Młynarski
Miron Chumiecki
Przemysława Jarosz-Chobot
Joanna Chrzanowska
Anna Noczyńska
Agnieszka Brandt
Małgorzata Myśliwiec
Barbara Głowińska-Olszewska
Paweł Bernatowicz
Oksana Kowalczuk
Artur Bossowski
Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
International Journal of Endocrinology
author_facet Włodzimierz Łuczyński
Wojciech Fendler
Anna Ramatowska
Agnieszka Szypowska
Agnieszka Szadkowska
Wojciech Młynarski
Miron Chumiecki
Przemysława Jarosz-Chobot
Joanna Chrzanowska
Anna Noczyńska
Agnieszka Brandt
Małgorzata Myśliwiec
Barbara Głowińska-Olszewska
Paweł Bernatowicz
Oksana Kowalczuk
Artur Bossowski
author_sort Włodzimierz Łuczyński
title Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_short Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_full Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_fullStr Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_full_unstemmed Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
title_sort polymorphism of the fto gene influences body weight in children with type 1 diabetes without severe obesity
publisher Hindawi Limited
series International Journal of Endocrinology
issn 1687-8337
1687-8345
publishDate 2014-01-01
description The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P=0.0003), poor metabolic control (P=0.0001), and carriage of the A allele of the FTO rs9939609 gene (P=0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).
url http://dx.doi.org/10.1155/2014/630712
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