Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Abstract Background Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis in PCa. However, clinical significance of miR-133a-3p in bone metastas...

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Bibliographic Details
Main Authors: Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He, Qingde Wa
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
miR-133a-3p
Cytokine receptor
Bone metastasis
PI3K/AKT signaling pathway
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s13046-018-0813-4

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