Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters

Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters

Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family, mainly expressed in insulin-sensitive tissues. HK2 induction in most neoplastic cells contributes to their metabolic rew...

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Bibliographic Details
Main Authors:	Francesco Ciscato, Lavinia Ferrone, Ionica Masgras, Claudio Laquatra, Andrea Rasola
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	International Journal of Molecular Sciences
Subjects:	hexokinase 2 mitochondria MAMs Ca<sup>2+</sup> tumor metabolism apoptosis
Online Access:	https://www.mdpi.com/1422-0067/22/9/4716

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