Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

Abstract Background Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia are activated and polarized to either the pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype, which act as a critical mediator of neuroinflammation. Sestrin2 has pro-survival properties again...

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Bibliographic Details
Main Authors: Tingting He, Wanlu Li, Yaying Song, Zongwei Li, Yaohui Tang, Zhijun Zhang, Guo-Yuan Yang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Autophagic flux
Inflammation
Ischemia
Microglia
mTOR
Online Access:http://link.springer.com/article/10.1186/s12974-020-01987-y

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http://link.springer.com/article/10.1186/s12974-020-01987-y

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