A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
Initially motivated by the analysis of the flow dynamics of the synovial fluid, taken as non-Newtonian, this paper also reports on a numerical challenge which occurred unexpectedly while solving the momentum equation of the model. The configuration consists of two infinitely long horizontal parallel...
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doaj-d5a7a83328c143c9a28108f57f9a0f5a2021-04-09T23:03:17ZengMDPI AGFluids2311-55212021-04-01615215210.3390/fluids6040152A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical ChallengeS. Canberk Ozan0Gérard Labrosse1A. Kerem Uguz2Department of Chemical Engineering, Bogazici University, 34342 Istanbul, TurkeyTchebyFlow SAS, 34000 Montpellier, FranceDepartment of Chemical Engineering, Bogazici University, 34342 Istanbul, TurkeyInitially motivated by the analysis of the flow dynamics of the synovial fluid, taken as non-Newtonian, this paper also reports on a numerical challenge which occurred unexpectedly while solving the momentum equation of the model. The configuration consists of two infinitely long horizontal parallel flat plates where the top plate is sheared at constant speed and the bottom plate is fixed. The synovial fluid shows a shear-thinning rheology, and furthermore it thickens with the hyaluronic acid (HA) concentration, i.e., it is also chemically-thickening. Accordingly, a modified Cross model is employed to express the shear rate and concentration-dependent viscosity, whose parameter values are determined from experimental data. Another significance of the study is the investigation of the effect of an external stimulus on the flow dynamics via a HA source term. The resulting flow exhibits peculiar features resulting from extremely large and small, but positive, numerical quantities, such as the viscosity and the shear rates. This requires constructing a parametrized zero-machine level solver, up to 300 accurate digits or so, for capturing the correct length scales of the flow physics. As a conclusion, the physical model, although simple, but original, leads to interesting results whose numerical determination turns out to be successful only once the real cause of the numerical trap is identified.https://www.mdpi.com/2311-5521/6/4/152synovial fluidhyaluronic acidshear-thinningchemically-thickeningvariable number of accurate digits |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. Canberk Ozan Gérard Labrosse A. Kerem Uguz |
spellingShingle |
S. Canberk Ozan Gérard Labrosse A. Kerem Uguz A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge Fluids synovial fluid hyaluronic acid shear-thinning chemically-thickening variable number of accurate digits |
author_facet |
S. Canberk Ozan Gérard Labrosse A. Kerem Uguz |
author_sort |
S. Canberk Ozan |
title |
A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge |
title_short |
A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge |
title_full |
A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge |
title_fullStr |
A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge |
title_full_unstemmed |
A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge |
title_sort |
model of synovial fluid with a hyaluronic acid source: a numerical challenge |
publisher |
MDPI AG |
series |
Fluids |
issn |
2311-5521 |
publishDate |
2021-04-01 |
description |
Initially motivated by the analysis of the flow dynamics of the synovial fluid, taken as non-Newtonian, this paper also reports on a numerical challenge which occurred unexpectedly while solving the momentum equation of the model. The configuration consists of two infinitely long horizontal parallel flat plates where the top plate is sheared at constant speed and the bottom plate is fixed. The synovial fluid shows a shear-thinning rheology, and furthermore it thickens with the hyaluronic acid (HA) concentration, i.e., it is also chemically-thickening. Accordingly, a modified Cross model is employed to express the shear rate and concentration-dependent viscosity, whose parameter values are determined from experimental data. Another significance of the study is the investigation of the effect of an external stimulus on the flow dynamics via a HA source term. The resulting flow exhibits peculiar features resulting from extremely large and small, but positive, numerical quantities, such as the viscosity and the shear rates. This requires constructing a parametrized zero-machine level solver, up to 300 accurate digits or so, for capturing the correct length scales of the flow physics. As a conclusion, the physical model, although simple, but original, leads to interesting results whose numerical determination turns out to be successful only once the real cause of the numerical trap is identified. |
topic |
synovial fluid hyaluronic acid shear-thinning chemically-thickening variable number of accurate digits |
url |
https://www.mdpi.com/2311-5521/6/4/152 |
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