A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge

Initially motivated by the analysis of the flow dynamics of the synovial fluid, taken as non-Newtonian, this paper also reports on a numerical challenge which occurred unexpectedly while solving the momentum equation of the model. The configuration consists of two infinitely long horizontal parallel...

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Main Authors: S. Canberk Ozan, Gérard Labrosse, A. Kerem Uguz
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Fluids
Subjects:
Online Access:https://www.mdpi.com/2311-5521/6/4/152
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spelling doaj-d5a7a83328c143c9a28108f57f9a0f5a2021-04-09T23:03:17ZengMDPI AGFluids2311-55212021-04-01615215210.3390/fluids6040152A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical ChallengeS. Canberk Ozan0Gérard Labrosse1A. Kerem Uguz2Department of Chemical Engineering, Bogazici University, 34342 Istanbul, TurkeyTchebyFlow SAS, 34000 Montpellier, FranceDepartment of Chemical Engineering, Bogazici University, 34342 Istanbul, TurkeyInitially motivated by the analysis of the flow dynamics of the synovial fluid, taken as non-Newtonian, this paper also reports on a numerical challenge which occurred unexpectedly while solving the momentum equation of the model. The configuration consists of two infinitely long horizontal parallel flat plates where the top plate is sheared at constant speed and the bottom plate is fixed. The synovial fluid shows a shear-thinning rheology, and furthermore it thickens with the hyaluronic acid (HA) concentration, i.e., it is also chemically-thickening. Accordingly, a modified Cross model is employed to express the shear rate and concentration-dependent viscosity, whose parameter values are determined from experimental data. Another significance of the study is the investigation of the effect of an external stimulus on the flow dynamics via a HA source term. The resulting flow exhibits peculiar features resulting from extremely large and small, but positive, numerical quantities, such as the viscosity and the shear rates. This requires constructing a parametrized zero-machine level solver, up to 300 accurate digits or so, for capturing the correct length scales of the flow physics. As a conclusion, the physical model, although simple, but original, leads to interesting results whose numerical determination turns out to be successful only once the real cause of the numerical trap is identified.https://www.mdpi.com/2311-5521/6/4/152synovial fluidhyaluronic acidshear-thinningchemically-thickeningvariable number of accurate digits
collection DOAJ
language English
format Article
sources DOAJ
author S. Canberk Ozan
Gérard Labrosse
A. Kerem Uguz
spellingShingle S. Canberk Ozan
Gérard Labrosse
A. Kerem Uguz
A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
Fluids
synovial fluid
hyaluronic acid
shear-thinning
chemically-thickening
variable number of accurate digits
author_facet S. Canberk Ozan
Gérard Labrosse
A. Kerem Uguz
author_sort S. Canberk Ozan
title A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
title_short A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
title_full A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
title_fullStr A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
title_full_unstemmed A Model of Synovial Fluid with a Hyaluronic Acid Source: A Numerical Challenge
title_sort model of synovial fluid with a hyaluronic acid source: a numerical challenge
publisher MDPI AG
series Fluids
issn 2311-5521
publishDate 2021-04-01
description Initially motivated by the analysis of the flow dynamics of the synovial fluid, taken as non-Newtonian, this paper also reports on a numerical challenge which occurred unexpectedly while solving the momentum equation of the model. The configuration consists of two infinitely long horizontal parallel flat plates where the top plate is sheared at constant speed and the bottom plate is fixed. The synovial fluid shows a shear-thinning rheology, and furthermore it thickens with the hyaluronic acid (HA) concentration, i.e., it is also chemically-thickening. Accordingly, a modified Cross model is employed to express the shear rate and concentration-dependent viscosity, whose parameter values are determined from experimental data. Another significance of the study is the investigation of the effect of an external stimulus on the flow dynamics via a HA source term. The resulting flow exhibits peculiar features resulting from extremely large and small, but positive, numerical quantities, such as the viscosity and the shear rates. This requires constructing a parametrized zero-machine level solver, up to 300 accurate digits or so, for capturing the correct length scales of the flow physics. As a conclusion, the physical model, although simple, but original, leads to interesting results whose numerical determination turns out to be successful only once the real cause of the numerical trap is identified.
topic synovial fluid
hyaluronic acid
shear-thinning
chemically-thickening
variable number of accurate digits
url https://www.mdpi.com/2311-5521/6/4/152
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