Effectiveness of medication in cluster headache
Abstract Background The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collection of data within the framework of citizen science projects opens up th...
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doaj-d5a313354f7346f1bddc60e740cdbcc82021-04-25T11:25:56ZengBMCBMC Neurology1471-23772021-04-012111810.1186/s12883-021-02195-8Effectiveness of medication in cluster headacheJohannes Drescher0Andreas Khouri1Tina Katharina Amann2Charly Gaul3Peter Kropp4Yannic Siebenhaar5Jörg Scheidt6Institute of Information Systems, University of Applied Sciences HofInstitute of Information Systems, University of Applied Sciences HofInstitute of Information Systems, University of Applied Sciences HofMigraine and Headache Clinic KönigsteinInstitute of Medical Psychology and Medical Sociology, University of RostockInstitute of Information Systems, University of Applied Sciences HofInstitute of Information Systems, University of Applied Sciences HofAbstract Background The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collection of data within the framework of citizen science projects opens up the possibility of investigating the effectiveness of acute medication on the basis of a large number of individual attacks instead of a simple survey of patients. Methods Data from 8369 cluster headache attacks, containing information about acute medication taken and the assessment of its effect, were collected from 133 participants using an online platform and a smartphone app. Chi-square tests were used to investigate whether the effect of the three recommended acute drugs differs when distinguishing between participants with chronic or episodic cluster headache. Furthermore, it was investigated whether there are differences between smokers and non-smokers in the assessment of the effect of the acute medication. Results Our participants rated the effectiveness of sumatriptan 6 mg s.c. as significantly better than oxygen and zolmitriptan nasal spray. Oxygen is considered to be significantly better in episodic versus chronic cluster headache, and sumatriptan is considered to be significantly better in chronic versus episodic cluster headache. Smokers rate the effect of oxygen as significantly better than non-smokers. Conclusions Despite some methodological limitations, web-based data collection is able to support findings from clinical trials in a real world setting about effectiveness of acute cluster headache treatment in several situations.https://doi.org/10.1186/s12883-021-02195-8Cluster headacheAcute medicationEffectivenessCitizen science |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johannes Drescher Andreas Khouri Tina Katharina Amann Charly Gaul Peter Kropp Yannic Siebenhaar Jörg Scheidt |
spellingShingle |
Johannes Drescher Andreas Khouri Tina Katharina Amann Charly Gaul Peter Kropp Yannic Siebenhaar Jörg Scheidt Effectiveness of medication in cluster headache BMC Neurology Cluster headache Acute medication Effectiveness Citizen science |
author_facet |
Johannes Drescher Andreas Khouri Tina Katharina Amann Charly Gaul Peter Kropp Yannic Siebenhaar Jörg Scheidt |
author_sort |
Johannes Drescher |
title |
Effectiveness of medication in cluster headache |
title_short |
Effectiveness of medication in cluster headache |
title_full |
Effectiveness of medication in cluster headache |
title_fullStr |
Effectiveness of medication in cluster headache |
title_full_unstemmed |
Effectiveness of medication in cluster headache |
title_sort |
effectiveness of medication in cluster headache |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2021-04-01 |
description |
Abstract Background The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collection of data within the framework of citizen science projects opens up the possibility of investigating the effectiveness of acute medication on the basis of a large number of individual attacks instead of a simple survey of patients. Methods Data from 8369 cluster headache attacks, containing information about acute medication taken and the assessment of its effect, were collected from 133 participants using an online platform and a smartphone app. Chi-square tests were used to investigate whether the effect of the three recommended acute drugs differs when distinguishing between participants with chronic or episodic cluster headache. Furthermore, it was investigated whether there are differences between smokers and non-smokers in the assessment of the effect of the acute medication. Results Our participants rated the effectiveness of sumatriptan 6 mg s.c. as significantly better than oxygen and zolmitriptan nasal spray. Oxygen is considered to be significantly better in episodic versus chronic cluster headache, and sumatriptan is considered to be significantly better in chronic versus episodic cluster headache. Smokers rate the effect of oxygen as significantly better than non-smokers. Conclusions Despite some methodological limitations, web-based data collection is able to support findings from clinical trials in a real world setting about effectiveness of acute cluster headache treatment in several situations. |
topic |
Cluster headache Acute medication Effectiveness Citizen science |
url |
https://doi.org/10.1186/s12883-021-02195-8 |
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