Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes

• Main Authors: Christos S. Derdemezis, Dimitrios N. Kiortsis, Vasilis Tsimihodimos, Maria P. Petraki, Patra Vezyraki, Moses S. Elisaf, Alexandros D. Tselepis
• Format: Article
• Language: English
• Published: Hindawi Limited 2011-01-01
• Series: Biochemistry Research International
• Online Access: http://dx.doi.org/10.1155/2011/285618

Introduction. Adipose tissue contributes to atherosclerosis with mechanisms related to adipokine secretion. Polyphenols may exhibit antiatherogenic properties. The aim of the study was to investigate the effects of three polyphenols, namely, quercetin, epigallocatechin gallate (EGCG), and resveratrol on adipokine secretion from cultured human adipocytes. Methods. Human SGBS adipocytes were treated with quercetin, EGCG, and resveratrol for 24 and 48 hours. Visfatin, leptin, and adiponectin were measured in the supernatant. Results. Visfatin secretion was inhibited by quercetin 10 μM by 16% and 24% at 24 and 48 hours respectively. The corresponding changes for quercetin 25 μM were 47% and 48%. Resveratrol 25 μM reduced visfatin by 28% and 38% at 24 and 48 hours. EGCG did not have an effect on visfatin. None of tested polyphenols influenced leptin and adiponectin secretion. Conclusion. Quercetin and resveratrol significantly decreased visfatin secretion from SGBS adipocytes. This effect may contribute to their overall antiatherogenic properties.