Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

Woodchuck Hepatitis Virus Post-transcriptional Regulatory Element (WPRE) is thought to enhance transgene expression of target genes delivered by adeno-associated viral (AAV) vectors. This study assessed the protein expression of α-synuclein, phosphorylated α-synuclein at Serine 129, extent of nigros...

Full description

Bibliographic Details
Main Authors:	Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	Heliyon
Subjects:	Parkinson's disease Synucleinopathy Woodchuck hepatitis virus post-transcriptional regulatory element Mouse
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844021004072

Similar Items

Alpha-synuclein in cutaneous small nerve fibers
by: Siepmann T, et al.
Published: (2016-10-01)

Multiple system atrophy: A prototypical synucleinopathy for disease-modifying therapeutic strategies
by: Pierre-Olivier Fernagut, et al.
Published: (2014-07-01)

Suitability of the woodchuck HCC as a preclinical model for evaluation of intra‐arterial therapies
by: Alexander Y. Kim, et al.
Published: (2020-03-01)

Vers l'imagerie in vivo de l'alpha-synucléine.
by: Levigoureux, Elise
Published: (2015)

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils
by: Joseph R. Patterson, et al.
Published: (2019-10-01)

Mechanism of Anti-α-Synuclein Immunotherapy
by: Jun Sung Lee, et al.
Published: (2016-01-01)

Chinese woodchucks with different susceptibility to WHV infection differ in their genetic background exemplified by cytochrome B and MHC-DRB molecules
by: Bin Zhu, et al.
Published: (2018-06-01)

Editorial: Intracellular Mechanisms of α-Synuclein Processing
by: Friederike Zunke, et al.
Published: (2021-09-01)

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
by: Kensuke Ikenaka, et al.
Published: (2019-07-01)

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
by: Julia E. Gerson, et al.
Published: (2018-03-01)

Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts
by: Špela Korat, et al.
Published: (2021-08-01)

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
by: Veronica Ghiglieri, et al.
Published: (2018-05-01)

Import and Export of Misfolded α-Synuclein
by: Lilia Rodriguez, et al.
Published: (2018-05-01)

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau
by: Maxime WC Rousseaux, et al.
Published: (2016-10-01)

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death
by: Lasse Reimer, et al.
Published: (2018-07-01)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
by: Antonio Heras-Garvin, et al.
Published: (2020-09-01)

Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
by: Francesca Longhena, et al.
Published: (2019-01-01)

Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
by: Luis D. Bernal-Conde, et al.
Published: (2020-01-01)

Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells
by: Jinar Rostami, et al.
Published: (2020-11-01)

Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease
by: Eileen Ruth S. Torres, et al.
Published: (2021-10-01)

Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits
by: Wouter Peelaerts, et al.
Published: (2020-11-01)

Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model
by: Alicia Flores-Cuadrado, et al.
Published: (2019-04-01)

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits
by: Penelope J. Hallett, et al.
Published: (2012-08-01)

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
by: David I. Finkelstein, et al.
Published: (2017-06-01)

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells
by: Cathryn L. Ugalde, et al.
Published: (2020-01-01)

The Concept of α-Synuclein Strains and How Different Conformations May Explain Distinct Neurodegenerative Disorders
by: Katja Malfertheiner, et al.
Published: (2021-10-01)

Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity
by: Sortwell, C.E, et al.
Published: (2022)

PET imaging of hepatocellular carcinoma with anti-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in comparison with l-[S-methyl-11C]methionine
by: Olga Sergeeva, et al.
Published: (2019-05-01)

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
by: Niccolo Candelise, et al.
Published: (2020-01-01)

A cell culture model for monitoring α-synuclein cell-to-cell transfer
by: Juan F. Reyes, et al.
Published: (2015-05-01)

Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
by: Alessandra Bigi, et al.
Published: (2021-05-01)

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
by: Javier María Peralta Ramos, et al.
Published: (2019-01-01)

Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
by: Jung-Youn Han, et al.
Published: (2021-04-01)

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
by: Makoto Hashimoto, et al.
Published: (2012-09-01)

α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?
by: Simon Oliver Hoppe, et al.
Published: (2021-06-01)

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods
by: Airi Tarutani, et al.
Published: (2018-04-01)

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
by: Hao Gu, et al.
Published: (2021-03-01)

Evaluation of blood flow as a route for propagation in experimental synucleinopathy
by: Xuan Yu, et al.
Published: (2021-03-01)

Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
by: Yaping Chu, et al.
Published: (2007-01-01)

A New Rise of Non-Human Primate Models of Synucleinopathies
by: Margaux Teil, et al.
Published: (2021-03-01)