Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

• Main Authors: Jiaolong Wang, Lilin Zhan, Xianhua Zhang, Runfa Wu, Lan Liao, Junchao Wei
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-04-01
• Series: Frontiers in Pharmacology
• Subjects: poly(L-lactide); electrospun; antibacterial; Ag nanoparticles; guided bone regeneration
• Online Access: https://www.frontiersin.org/article/10.3389/fphar.2020.00431/full

Bacterial infection has been a critic problem for implant infections. Poly(L-lactide) (PLLA) membrane has great potential for Guided bone regeneration (GBR), however, PLLA lack antibacterial property and thus may face bacterial infections. In this work, a mussel inspired method was used to treat PLLA membrane with dopamine and formed polydopamine (PDA) coated PLLA (PLLA@PDA), and then silver Nanoparticles (AgNPs) was immobilized on the surface of PLLA via the reduction effect of PDA. The XPS results showed that the silver element contents may be tuned from 1.6% to 15.4%. The AgNPs coated PLLA (PLLA@Ag) showed good antibacterial property (98.3% bactericidal efficiency may be obtained) and good biocompatibility, implying that the PLLA@Ag membrane have potential application as antibacterial GBR membrane, which may enhance the application of PLLA.